Definition
An expression used to indicate annoyance or disagreement with what someone has just said.
（表示恼怒或不同意）你是什么意思？
What do you mean by saying that? Are you implying I should take the blame?
你这么说是什么意思？你是暗示我应该承担责任吗？
What do you mean by that? I don't understand your implication.
你这么说是什么意思？我不明白你的言外之意。
Wait, what do you mean by that? I consider this to be an unfair accusation.
等等，你这么说是什么意思？我认为这是一个不公平的指控。