Definition
To be so worried, confused, or frustrated that you do not know what to do next; to be at a loss as to what to do.
寧無辦法
After trying for hours, I was at my wits' end with the problem.
嘗試了幾個小時後，我對這個問題已經束手無策了。
She was at her wits' end, not knowing how to deal with her teenage son.
她對如何管教她十幾歲的兒子已經無計可施了。
After searching for the missing keys for hours, I was truly at my wits' end.
在找了幾個小時丟失的鑰匙後，我真的已經無計可施了。