Definition
To progress and conclude naturally, without intervention.
自然发展至结束
This project has many problems; maybe it's best to let it run its course.
这个项目有很多问题；也许最好让它自然发展。
This epidemic has to run its course before it disappears.
这场疫情必须自然发展，直到消失。
Our argument will run its course eventually; no need to worry too much about it.
我们的争论最终会自然结束；不用太担心。