Definition
To progress and conclude naturally, without intervention.
自然發展至結束
This project has many problems; maybe it's best to let it run its course.
這個專案有很多問題；也許最好讓它自然發展。
This epidemic has to run its course before it disappears.
這場疫情必須自然發展，直到消失。
Our argument will run its course eventually; no need to worry too much about it.
我們的爭論最終會自然結束；不用太擔心。