Definition
An exclamation of disbelief or rejection of what someone has said; implying that the speaker believes the other person is being dishonest or disingenuous.
"I just accidentally spilled coffee on your new shirt." "Don't give me that! You did it on purpose!"
"I really don't know how the money disappeared." "Don't give me that! I know you took it."
"I just got a little delayed on the way." "Don't give me that! You clearly overslept."