Definition
an impolite expression used to describe causing damage, harm, distress, or failing at a task severely
弄坏；破坏；使困扰；搞砸
His carelessness really fucked up the entire project.
他的粗心大意真的搞砸了整个项目。
If we don't double-check, we might fuck up the key data in the report and ruin the presentation.
如果我们不仔细检查，可能会搞砸报告中的关键数据，毁了整个演示。
She didn’t know how to use the new software, and in the end, she fucked up the system.
她不知道如何使用新软件，最后把系统搞坏了。