Definition
To screw someone up means to induce anxiety, distress, or cause lasting psychological issues, often due to negative experiences or individuals.
令（某人）焦慮；讓（某人）痛苦；使（某人）心理崩潰
His parents' divorce really screwed him up, leaving him feeling extremely anxious.
他父母的離婚真的讓他崩潰了，使他感到極度焦慮。
The teacher's harsh criticism screwed her up so much that it damaged her self-esteem.
老師的嚴厲批評讓她崩潰到損害了她的自尊心。
The toxic environment he worked in screwed him up psychologically.
他工作的有毒環境讓他在心理上崩潰了。